Type

Journal Article

Authors

Aiden Peter Corvin
Michael Gill
Gary (James) Donohoe
Derek Morris

Subjects

Psychiatry

Topics
hlac schizophrenia cacna1i polygene score major histocompatibility complex genome wide association study single nucleotide polymorphisms genetics

Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia. (2012)

Abstract Background? We performed a genome-wide association study (GWAS) to identify common risk variants for schizophrenia. Methods? The discovery scan included 1606 patients and 1794 controls from Ireland, using 6,212,339 directly genotyped or imputed single nucleotide polymorphisms (SNPs). A subset of this sample (270 cases and 860 controls) was subsequently included in the Psychiatric GWAS Consortium-schizophrenia GWAS meta-analysis. Results? One hundred eight SNPs were taken forward for replication in an independent sample of 13,195 cases and 31,021 control subjects. The most significant associations in discovery, corrected for genomic inflation, were (rs204999, p combined = 1.34 ? 10 ?9 and in combined samples (rs2523722 p combined = 2.88 ? 10 ?16 ) mapped to the major histocompatibility complex (MHC) region. We imputed classical human leukocyte antigen (HLA) alleles at the locus; the most significant finding was with HLA-C*01:02. This association was distinct from the top SNP signal. The HLA alleles DRB1*03:01 and B*08:01 were protective, replicating a previous study. Conclusions? This study provides further support for involvement of MHC class I molecules in schizophrenia. We found evidence of association with previously reported risk alleles at the TCF4,VRK2, and ZNF804A loci
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Full list of authors on original publication

Aiden Peter Corvin, Michael Gill, Gary (James) Donohoe, Derek Morris

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
4
Derek Morris
Trinity College Dublin
Total Publications: 150