Type

Journal Article

Authors

Aiden Peter Corvin
Michael Gill
Derek Morris

Subjects

Psychiatry

Topics
etiology of schizophrenia runs of homozygosity bias genome controls association alleles risk factor

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. (2012)

Abstract Autozygosity occurs when two chromosomal segments that are identical from a common ancestor are inherited from each parent. This occurs at high rates in the offspring of mates who are closely related (inbreeding), but also occurs at lower levels among the offspring of distantly related mates. Here, we use runs of homozygosity in genome-wide SNP data to estimate the proportion of the autosome that exists in autozygous tracts in 9,388 cases with schizophrenia and 12,456 controls. We estimate that the odds of schizophrenia increase by , 17% for every 1% increase in genome-wide autozygosity. This association is not due to one or a few regions, but results from many autozygous segments spread throughout the genome, and is consistent with a role for multiple recessive or partially recessive alleles in the etiology of schizophrenia. Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time.
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Full list of authors on original publication

Aiden Peter Corvin, Michael Gill, Derek Morris

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Derek Morris
Trinity College Dublin
Total Publications: 150