Type

Journal Article

Authors

Gary (James) Donohoe
Michael Gill
Aiden Peter Corvin
Derek Morris

Subjects

Psychiatry

Topics
bipolar disorder genetic variation loci psychiatry schizophrenia european genome wide association study size

Genome-wide association study identifies five new schizophrenia loci. (2011)

Abstract We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding ( P = 1.6 ? 10 ? 11 ) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137 , suggesting MIR137 -mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 ? 10 ? 9 ), ANK3 (rs10994359, P = 2.5 ? 10 ? 8 ) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 ? 10 ? 9 ).
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Full list of authors on original publication

Gary (James) Donohoe, Michael Gill, Aiden Peter Corvin, Derek Morris

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Michael Gill
Trinity College Dublin
Total Publications: 260
 
3
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
4
Derek Morris
Trinity College Dublin
Total Publications: 150