Type

Journal Article

Authors

Aiden Corvin
Richard Reilly
Gary Donohoe
Michael Gill
Ronan Lyne
Sinead Kelly
Carol O'Brien
Derek Morris
Emma Jane Rose
Ciara Fahey
and 1 others

Subjects

Psychiatry

Topics
next generation medical devices schizophrenia neuronal activity cognitive psychology neuroscience functional connectivity affective symptoms psychology prefrontal cortex genes society rc0321 neuroscience biological psychiatry neuropsychiatry mir137 brain development

Effects of MIR137 on fronto-amygdala functional connectivity. (2014)

Abstract MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with schizophrenia, and with altered amygdala activation in those at genetic risk for schizophrenia. Following this evidence, we investigated the effects of MIR137 genotype on neuronal activity during face processing. Methods By grouping 81 healthy participants as carrier or non-carriers of the MIR137 rs1625579 risk allele associated with schizophrenia, we investigated MIR137's effects on altered cortical response during an fMRI face processing task and altered functional connectivity using the amygdala as a seed region. Results Homozygous carriers of the risk allele were observed to show relatively increased functional connectivity between the right amygdala and frontal regions that play a key role in emotion processing and regulation (e.g. the cingulate and prefrontal cortex). Conclusions Our findings provide the first evidence that the rs1625579 variant affects fronto-amygdala functional connectivity, providing further evidence that MIR137 may contribute to forms of psychosis in which affective symptoms are more prominent.
Collections Ireland -> National College Ireland -> Subject = R Medicine: RC Internal medicine: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognitive psychology
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> National College Ireland -> Subject = R Medicine
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> Trinity College Dublin -> Psychiatry
Ireland -> National College Ireland -> Subject = R Medicine: RC Internal medicine
Ireland -> Trinity College Dublin -> School of Medicine
Ireland -> Trinity College Dublin -> Psychiatry (Scholarly Publications)
Ireland -> National College Ireland -> Type = Article
Ireland -> Trinity College Dublin -> RSS Feeds

Full list of authors on original publication

Aiden Corvin, Richard Reilly, Gary Donohoe, Michael Gill, Ronan Lyne, Sinead Kelly, Carol O'Brien, Derek Morris, Emma Jane Rose, Ciara Fahey and 1 others

Experts in our system

1
Aiden Corvin
Trinity College Dublin
Total Publications: 218
 
2
Richard Reilly
Trinity College Dublin
Total Publications: 195
 
3
Gary Donohoe
Trinity College Dublin
Total Publications: 162
 
4
Michael Gill
Trinity College Dublin
Total Publications: 294
 
5
Sinead Kelly
National College Ireland
Total Publications: 22
 
6
Derek Morris
Trinity College Dublin
Total Publications: 168