Type

Journal Article

Authors

Michael Gill
Aiden Corvin
Derek Morris
Gary Donohoe
Elizabeth Heron

Subjects

Psychiatry

Topics
individual runs of homozygosity irish genome genome wide association schizophrenia dataset genome wide association study psychiatry

No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset (2014)

Abstract Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p = 0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.
Collections Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> Psychiatry (Scholarly Publications)
Ireland -> Trinity College Dublin -> Psychiatry
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> School of Medicine

Full list of authors on original publication

Michael Gill, Aiden Corvin, Derek Morris, Gary Donohoe, Elizabeth Heron

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 260
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
3
Derek Morris
Trinity College Dublin
Total Publications: 150
 
4
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
5
Elizabeth Heron
Trinity College Dublin
Total Publications: 14