Type

Journal Article

Authors

Michael Gill
Derek Morris

Subjects

Psychiatry

Topics
bipolar disorder meta analysis risk factors psychiatry body mass index family members genome wide association study follow up

Common variant at 16p11.2 conferring risk of psychosis (2012)

Abstract Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as many as 18?206 cases and 42?536 controls), we identified four loci showing genome-wide significant association with schizophrenia. Here we consider a mixed schizophrenia and bipolar disorder (psychosis) phenotype (addition of 7469 bipolar disorder cases, 1535 schizophrenia cases, 333 other psychosis cases, 808 unaffected family members and 46?160 controls). Combined analysis reveals a novel variant at 16p11.2 showing genome-wide significant association (rs4583255[T]; odds ratio=1.08; P=6.6 ? 10(-11)). The new variant is located within a 593-kb region that substantially increases risk of psychosis when duplicated. In line with the association of the duplication with reduced body mass index (BMI), rs4583255[T] is also associated with lower BMI (P=0.0039 in the public GIANT consortium data set; P=0.00047 in 22?651 additional Icelanders).
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Full list of authors on original publication

Michael Gill, Derek Morris

Experts in our system

1
Michael Gill
Trinity College Dublin
Total Publications: 273
 
2
Derek Morris
Trinity College Dublin
Total Publications: 156