Type

Journal Article

Authors

Derek Morris
Aiden Corvin
Michael Gill
Gary Donohoe
Lorna Lopez

Subjects

Psychiatry

Topics
variants alzheimer s disease human genetics genome wide association brain tissue candidate gene hippocampal magnetic resonance imaging mri genes society epilepsy temporal lobe neuroscience

Identification of common variants associated with human hippocampal and intracranial volumes (2012)

Abstract Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 ? 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 ? 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 ? 10(-7))
Collections Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> Psychiatry (Scholarly Publications)
Ireland -> Trinity College Dublin -> Psychiatry
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> Trinity College Dublin -> School of Medicine

Full list of authors on original publication

Derek Morris, Aiden Corvin, Michael Gill, Gary Donohoe, Lorna Lopez

Experts in our system

1
Derek Morris
Trinity College Dublin
Total Publications: 168
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 218
 
3
Michael Gill
Trinity College Dublin
Total Publications: 294
 
4
Gary Donohoe
Trinity College Dublin
Total Publications: 162
 
5
Lorna Lopez
Royal College of Surgeons in Ireland
Total Publications: 17