Journal Article


Kang Sim
Yih Yian Sitoh
Ta Ahn Tuan
Carissa Nadia Kuswanto
Min Yi Sum
Anqi Qiu
Gary Donohoe
Jamie Yu Jin Thong



hippocampus central nervous system genotype female human genetics metabolism male diagnostic imaging blood middle aged variant brain mapping thalamus schizophrenia cerebral cortex deformation radiography thalamic nuclei morphology neurogranin adult nrgn protein human magnetic resonance imaging humans basal ganglia

Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia. (2013)

Abstract Although the genome wide supported psychosis susceptibility neurogranin (NRGN) gene is expressed in human brains, it is unclear how it impacts brain morphology in schizophrenia. We investigated the influence of NRGN rs12807809 on cortical thickness, subcortical volumes and shapes in patients with schizophrenia. One hundred and fifty six subjects (91 patients with schizophrenia and 65 healthy controls) underwent structural MRI scans and their blood samples were genotyped. A brain mapping algorithm, large deformation diffeomorphic metric mapping, was used to perform group analysis of subcortical shapes and cortical thickness. Patients with risk TT genotype were associated with widespread cortical thinning involving frontal, parietal and temporal cortices compared with controls with TT genotype. No volumetric difference in subcortical structures (hippocampus, thalamus, amygdala, basal ganglia) was observed between risk TT genotype in patients and controls. However, patients with risk TT genotype were associated with thalamic shape abnormalities involving regions related to pulvinar and medial dorsal nuclei. Our results revealed the influence of the NRGN gene on thalamocortical morphology in schizophrenia involving widespread cortical thinning and thalamic shape abnormalities. These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophrenia
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Full list of authors on original publication

Kang Sim, Yih Yian Sitoh, Ta Ahn Tuan, Carissa Nadia Kuswanto, Min Yi Sum, Anqi Qiu, Gary Donohoe, Jamie Yu Jin Thong

Experts in our system

Gary Donohoe
Trinity College Dublin
Total Publications: 143