Type

Journal Article

Authors

Nadia Bolshakova
Louise Gallagher
Alison Merikangas
Michael Gill

Subjects

Psychiatry

Topics
control groups autism neuroscience cellular pathways intellectual disability convergence odds ratio copy number variation genes society single nucleotide fragile x syndrome autism spectrum disorders

Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders (2014)

Abstract Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus control groups (1.41-fold, p = 1.0 × 10−5) and an increase in affected subjects carrying exonic pathogenic CNVs overlapping known loci associated with dominant or X-linked ASD and intellectual disability (odds ratio = 12.62, p = 2.7 × 10−15, ∼3% of ASD subjects). Pathogenic CNVs, often showing variable expressivity, included rare de novo and inherited events at 36 loci, implicating ASD-associated genes (CHD2, HDAC4, and GDI1) previously linked to other neurodevelopmental disorders, as well as other genes such as SETD5, MIR137, and HDAC9. Consistent with hypothesized gender-specific modulators, females with ASD were more likely to have highly penetrant CNVs (p = 0.017) and were also overrepresented among subjects with fragile X syndrome protein targets (p = 0.02). Genes affected by de novo CNVs and/or loss-of-function single-nucleotide variants converged on networks related to neuronal signaling and development, synapse function, and chromatin regulation.
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Full list of authors on original publication

Nadia Bolshakova, Louise Gallagher, Alison Merikangas, Michael Gill

Experts in our system

1
Louise Gallagher
Trinity College Dublin
Total Publications: 59
 
2
Michael Gill
Trinity College Dublin
Total Publications: 273