Type

Journal Article

Authors

Kevin Kavanagh
Martin Clynes
Steven Verhaegen
Paul Daly

Subjects

Microbiology

Topics
aspergillus fumigatus modes cell death cancer cells a549 cells cancer cell culture cancer cell lines human cell culture

Culture filtrates of Aspergillus fumigatus induce different modes of cell death in human cancer cell lines (1999)

Abstract Aspergillus fumigatus culture filtrate (CF) has a potent cytotoxic effect on three human cancer cell lines (DLKP, A549 and HEp-2) and initiates cell death by apoptosis but the execution of the apoptotic process is incomplete. DLKP cells treated with A. fumigatus CF demonstrate features associated with apoptosis but cytoplasmic and nuclear fragmentation were not observed and cells ultimately underwent necrosis. The apoptotic process commenced in A549 and HEp-2 cells upon exposure to CF, cell shrinkage was observed but membrane blebbing and apoptotic body formation were not detected and detached cells died by necrosis. In contrast, extensive nuclear fragmentation and apoptotic body formation were evident in DLKP and A549 cells treated with anti-neoplastic agents. This work indicates that A. fumigatus CF is cytotoxic to cancer cells and can initiate apoptosis but that the complete apoptotic pathway is not followed.
Collections Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Biology
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset

Full list of authors on original publication

Kevin Kavanagh, Martin Clynes, Steven Verhaegen, Paul Daly

Experts in our system

1
Kevin Kavanagh
Maynooth University
Total Publications: 139
 
2
Martin Clynes
Dublin City University
Total Publications: 209
 
3
Paul Daly
Maynooth University
Total Publications: 8