Type

Journal Article

Authors

Lorraine Brennan
Michael J Gibney
Anne P Nugent
Breige A McNulty
Albert Flynn
Milena Rundle
Janette Walton
Charlotte J. R. Michielsen
Helena Gibbons
Gary Frost

Subjects

Agriculture & Food Science

Topics
food intake dietary assessment calibration curves proline betaine citrus fruit dose response relationship orange juice national nutrition survey dose response dietary intake nmr spectroscopy metabolomics

Demonstration of the utility of biomarkers for dietary intake assessment; proline betaine as an example (2017)

Abstract Scope: There is a dearth of studies demonstrating the use of dietary biomarkers for determination of food intake. The objective of this study was to develop calibration curves for use in quantifying citrus intakes in an independent cohort. Methods and results: Participants (n=50) from the NutriTech food-intake study consumed standardized breakfasts for three consecutive days over three consecutive weeks. Orange juice intake decreased over the weeks. Urine samples were analyzed by NMR-spectroscopy and proline betaine was quantified and normalized to osmolality. Calibration curves were developed and used to predict citrus intake in an independent cohort; the Irish National Adult Nutrition Survey (NANS) (n=565). Proline betaine displayed a dose-response relationship to orange juice intake in 24h and fasting samples (p<0.001). In a test set, predicted orange juice intakes displayed excellent agreement with true intake. There were significant associations between predicted intake measured in 24h and fasting samples and true intake(r=0.710- 0.919). Citrus intakes predicted for the NANS cohort demonstrated good agreement with self-reported intake and this agreement improved following normalization to osmolality. Conclusion: The developed calibration curves successfully predicted citrus intakes in an independent cohort. Expansion of this approach to other foods will be important for the development of objective intake measurements.
Collections Ireland -> University College Dublin -> School of Agriculture and Food Science
Ireland -> University College Dublin -> Agriculture and Food Science Research Collection

Full list of authors on original publication

Lorraine Brennan, Michael J Gibney, Anne P Nugent, Breige A McNulty, Albert Flynn, Milena Rundle, Janette Walton, Charlotte J. R. Michielsen, Helena Gibbons, Gary Frost

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Michael J Gibney
University College Dublin
Total Publications: 102
 
3
Anne P Nugent
University College Cork
 
4
Breige A McNulty
University College Cork
 
5
Albert Flynn
University College Cork
Total Publications: 83
 
6
Milena Rundle
University College Dublin
Total Publications: 6
 
7
Janette Walton
University College Cork
Total Publications: 79
 
8
Helena Gibbons
University College Dublin
 
9
Gary Frost
University College Dublin
Total Publications: 6