Type

Journal Article

Authors

Joanna F Collingwood
Jon Dobson
Belinda Grehan
Mary E Finnegan
Marina Annetta Lynch
Joseph J Gallagher

Subjects

Biochemistry

Topics
mice microglial activation mice inbred c57bl mice transgenic brain iron brain tissue alzheimer s disease microglia amyloid beta protein precursor pathology metabolism spectrometry oxidative stress animals female x ray fluorescence plaque amyloid

Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress. (2011)

Abstract There is a well-established literature indicating a relationship between iron in brain tissue and Alzheimer's disease (AD). More recently, it has become clear that AD is associated with neuroinflammatory and oxidative changes which probably result from microglial activation. In this study, we investigated the correlative changes in microglial activation, oxidative stress, and iron dysregulation in a mouse model of AD which exhibits early-stage amyloid deposition. Microfocus X-ray absorption spectroscopy analysis of intact brain tissue sections prepared from A?PP/PS1 transgenic mice revealed the presence of magnetite, a mixed-valence iron oxide, and local elevations in iron levels in tissue associated with amyloid-?-containing plaques. The evidence indicates that the expression of markers of microglial activation, CD11b and CD68, and astrocytic activation, GFAP, were increased, and were histochemically determined to be adjacent to amyloid-?-containing plaques. These findings support the contention that, in addition to glial activation and oxidative stress, iron dysregulation is an early event in AD pathology.
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Full list of authors on original publication

Joanna F Collingwood, Jon Dobson, Belinda Grehan, Mary E Finnegan, Marina Annetta Lynch, Joseph J Gallagher

Experts in our system

1
Marina Annetta Lynch
Trinity College Dublin
Total Publications: 80