Type

Journal Article

Authors

Sabina Brennan
Thomas J. Connor
Ian Robertson
Eleonora Greco
Claire Mcdonald
Raasay S. Jones
Marina Lynch
Eric J. Downer

Subjects

Microbiology

Topics
dendritic cells macrophages blood mononuclear cells central nervous system amyloid beta protein immunology inflammation infection mild cognitive impairment cytokine production signal transduction microglial activation toll like receptors tlrs immune system inflammatory diseases alzheimer disease memory alzheimers disease cytokines inflammation

Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory (2013)

Abstract Background Cells of the innate immune system including monocytes and macrophages are the first line of defence against infections and are critical regulators of the inflammatory response. These cells express toll-like receptors (TLRs), innate immune receptors which govern tailored inflammatory gene expression patterns. Monocytes, which produce pro-inflammatory mediators, are readily recruited to the central nervous system (CNS) in neurodegenerative diseases. Methods This study explored the expression of receptors (CD11b, TLR2 and TLR4) on circulating monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs) isolated from healthy elderly adults who we classified as either IQ memory-consistent (high-performing, HP) or IQ memory-discrepant (low-performing, LP). Results The expression of CD11b, TLR4 and TLR2 was increased in MDMs from the LP group when compared to HP cohort. MDMs from both groups responded robustly to treatment with the TLR4 activator, lipopolysaccharide (LPS), in terms of cytokine production. Significantly, MDMs from the LP group displayed hypersensitivity to LPS exposure. Interpretation Overall these findings define differential receptor expression and cytokine profiles that occur in MDMs derived from a cohort of IQ memory-discrepant individuals. These changes are indicative of inflammation and may be involved in the prodromal processes leading to the development of neurodegenerative disease.
Collections Ireland -> Trinity College Dublin -> Physiology (Scholarly Publications)
Ireland -> University College Cork -> Anatomy and Neuroscience - Journal Articles
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> University College Cork -> College of Medicine and Health
Ireland -> Trinity College Dublin -> RSS Feeds
Ireland -> University College Cork -> Anatomy and Neuroscience
Ireland -> Trinity College Dublin -> Physiology
Ireland -> Trinity College Dublin -> School of Medicine

Full list of authors on original publication

Sabina Brennan, Thomas J. Connor, Ian Robertson, Eleonora Greco, Claire Mcdonald, Raasay S. Jones, Marina Lynch, Eric J. Downer

Experts in our system

1
Sabina Brennan
National College Ireland
Total Publications: 47
 
2
Thomas J Connor
Trinity College Dublin
Total Publications: 17
 
3
Ian H Robertson
Trinity College Dublin
Total Publications: 162
 
4
Marina Annetta Lynch
Trinity College Dublin
Total Publications: 80
 
5
Eric J. Downer
University College Cork
Total Publications: 25