Type

Conference Proceedings

Authors

Jens Ducree
Richard O'Kennedy
Darren McAuley
Domhnall Kelly
Shikha Sharma
Julia Zapatero-Rodríguez
Rohit Mishra

Subjects

Biochemistry

Topics
centrifugal microfluidics microfluidics biotechnology immunology lab on a disc dissolvable film valving prostate cancer immunoassays

Automation of heterogeneous prostate cancer immunoassay based on multi-valve triggering using purely rotational flow control (2016)

Abstract A multi-marker approach is increasingly considered in diagnosis of prostate cancer to minimize the number of unnecessary biopsies [1]. Centrifugo-pneumatic flow control is often the method of choice for multiplexing such assays [2]. However, the number of assays that can be parallelized on such a dissolvable-film (DF) based system is limited by the substantial spread of the burst frequencies [2] owing to manufacturing tolerances. In this work we substantially enhance the definition of actuation frequencies by 75% using a novel design to enable the automation of multi-step / multi-reagent Lab-on-a-Disc (LoaD) platform. We demonstrate a multi-marker prostate cancer immunoassay panel.
Collections Ireland -> Dublin City University -> Publication Type = Conference or Workshop Item
Ireland -> Dublin City University -> Status = Published
Ireland -> Dublin City University -> Subject = Biological Sciences: Microfluidics
Ireland -> Dublin City University -> DCU Faculties and Centres = Research Initiatives and Centres: Biomedical Diagnostics Institute (BDI)
Ireland -> Dublin City University -> Subject = Biological Sciences: Immunology
Ireland -> Dublin City University -> Subject = Biological Sciences: Biotechnology
Ireland -> Dublin City University -> DCU Faculties and Centres = DCU Faculties and Schools: Faculty of Science and Health: School of Physical Sciences

Full list of authors on original publication

Jens Ducree, Richard O'Kennedy, Darren McAuley, Domhnall Kelly, Shikha Sharma, Julia Zapatero-Rodríguez, Rohit Mishra

Experts in our system

1
Jens Ducree
Dublin City University
Total Publications: 83
 
2
R O'Kennedy
Dublin City University
Total Publications: 197
 
3
Shikha Sharma
Dublin City University
Total Publications: 10
 
4
Julia Zapatero-Rodríguez
Dublin City University
Total Publications: 6
 
5
Rohit Mishra
Dublin City University
Total Publications: 11