Type

Journal Article

Authors

Peter O'Gorman
Paul Dowling
Despina Bazou
Paula Meleady
Martin Clynes
Annemarie Larkin
Justine Meiller
Michael Henry
Kay Reen Ting

Subjects

Pharmacology

Topics
beta 2 microglobulin scoring system mass spectrometry protein multiple myeloma complement c1q international system patients

Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients. (2017)

Abstract Multiple myeloma (MM) is a complex heterogeneous disease. Various risk stratification models have been recommended including cytogenetic and FISH analysis to identify high-risk patients who may benefit from novel treatments, but such facilities are not widely available. The International Scoring System (ISS) using beta-2-microglobulin and albumin remains a widely used prognostic scoring system in many clinical practices; however it is not useful in predicting response to treatment in MM. The aim of this study is to identify clinically useful biomarkers to predict response to treatment containing bortezomib. 17 MM patient serum samples (9 responders/8 non-responders) were used for the discovery phase (label-free mass spectrometry) and an additional 20 MM patient serum samples were used for the ELISA-based validation phase (14 responders/6 non-responders). CLU and ANG mean levels were higher in the responders group, while Complement C1q had lower concentrations. The combination of all standard biomarkers (albumin, beta-2-microglobulin (ß2M), paraprotein and kappa/lambda (K/L) ratio) had an AUC value of 0.71 with 65% correct classification, while an overall combination of new candidate protein biomarkers with standard biomarkers had an AUC value of 0.89 with 85.3% correct classification. A combination of new and standard biomarkers consisting of CLU, ANG, C1Q, albumin, ß2M, paraprotein and K/L ratio may have potential as a novel panel of biomarkers to predict MM response to treatment containing bortezomib. Use of this biomarker panel could facilitate a more personalized therapy approach and to minimize unnecessary side effects from ineffective drugs.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Peter O'Gorman, Paul Dowling, Despina Bazou, Paula Meleady, Martin Clynes, Annemarie Larkin, Justine Meiller, Michael Henry, Kay Reen Ting

Experts in our system

1
Peter O'Gorman
Dublin City University
Total Publications: 15
 
2
Paul Dowling
Dublin City University
Total Publications: 79
 
3
Paula Meleady
Dublin City University
Total Publications: 95
 
4
Martin Clynes
Dublin City University
Total Publications: 209
 
5
Annemarie Larkin
Dublin City University
Total Publications: 25
 
6
Justine Meiller
Dublin City University
Total Publications: 7
 
7
Michael Henry
Dublin City University
Total Publications: 78