Type

Journal Article

Authors

Mark P Purdue
Dalsu Baris
Yawei Zhang
Dennis Weisenburger
Guido Tricot
Anthony Staines
Alexandra Nieters
Kirsten Moysich
Marc Maynadié
Graham G Giles
and 17 others

Subjects

Physiotherapy & Sport

Topics
international risk analysis case control studies young adult risk factors multiple myeloma logistic regression analysis body mass index

Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC). (2016)

Abstract Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI.Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls.Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m(2) increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P = 0.007]. We observed significant heterogeneity by study design (P = 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend = 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m(2); OR, 1.2; 95% CI, 1.1-1.3; P = 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction <0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-<30 kg/m(2)) or obese (30+ kg/m(2)) in both younger and usual adulthood (vs. individuals consistently <25 kg/m(2)), but not for those overweight or obese at only one time period.Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood.Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention. Cancer Epidemiol Biomarkers Prev; 26(6); 876-85. ©2017 AACR.
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Full list of authors on original publication

Mark P Purdue, Dalsu Baris, Yawei Zhang, Dennis Weisenburger, Guido Tricot, Anthony Staines, Alexandra Nieters, Kirsten Moysich, Marc Maynadié, Graham G Giles and 17 others

Experts in our system

1
Anthony Staines
Dublin City University
Total Publications: 96
 
2
Graham G Giles
Dublin City University
Total Publications: 17