Type

Journal Article

Authors

Brendan Egan
Giuseppe De Vito
Sinead B Bleiel
Alessandro Scotto di Palumbo
Robert M Kent
Michelle Hone

Subjects

Medicine & Nursing

Topics
blood adult male milk proteins double blind method humans eating protein hydrolysates healthy volunteers phytosterols diosgenin creatine dietary supplement sport random allocation pharmacokinetics biological availability drug compounding administration dosage drug stability

Plasma Creatine Kinetics After Ingestion of Microencapsulated Creatine Monohydrate with Enhanced Stability in Aqueous Solutions. (2017)

Abstract Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencapsulated CRE (3-g creatine monohydrate; n = 5) conditions. Experimental conditions involved ingestion of the samples in a 70-mL ready-to-drink format. CRE was delivered in a novel microencapsulation matrix material consisting entirely of hydrolyzed milk protein. Three hours after ingestion, plasma creatine concentrations were unchanged during PLA, and averaged ∼45 μM. During CRE, plasma creatine concentration peaked after 30 min at 101.6 ± 14.9 μM (p < 0.05), representing a 2.3-fold increase over PLA. Thereafter, plasma creatine concentration gradually trended downwards but remained significantly elevated (∼50% above resting levels) 3 hr after ingestion. These results demonstrate that the microencapsulated form of creatine monohydrate reported herein remains bioavailable when delivered in aqueous conditions, and has potential utility in ready-to-drink formulations for creatine supplementation.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Brendan Egan, Giuseppe De Vito, Sinead B Bleiel, Alessandro Scotto di Palumbo, Robert M Kent, Michelle Hone

Experts in our system

1
Brendan Egan
Dublin City University
Total Publications: 51
 
2
Giuseppe De Vito
University College Dublin
Total Publications: 47
 
3
Sinead B Bleiel
Royal College of Surgeons in Ireland
 
4
Michelle Hone
Dublin City University