Type

Journal Article

Authors

Kate Irving
Kevin Power
Marjan van den Akker
Frans R J Verhey
Muriel Redmond
Sebastian Köhler
Valeria Manera
Martin P J van Boxtel
Kay Deckers
Alex McConnachie
and 3 others

Subjects

Medicine & Nursing

Topics
coronary heart disease primary care blood pressure randomised controlled trial risk factors high pressure health behaviour controlled study

Reducing dementia risk by targeting modifiable risk factors in mid-life: study protocol for the Innovative Midlife Intervention for Dementia Deterrence (In-MINDD) randomised controlled feasibility trial. (2015)

Abstract Dementia prevalence is increasing as populations live longer, with no cure and the costs of caring exceeding many other conditions. There is increasing evidence for modifiable risk factors which, if addressed in mid-life, can reduce the risk of developing dementia in later life. These include physical inactivity, low cognitive activity, mid-life obesity, high blood pressure, and high cholesterol. This study aims to assess the acceptability and feasibility and impact of giving those in mid-life, aged between 40 and 60 years, an individualised dementia risk modification score and profile and access to personalised on-line health information and goal setting in order to support the behaviour change required to reduce such dementia risk. A secondary aim is to understand participants' and practitioners' views of dementia prevention and explore the acceptability and integration of the Innovative Midlife Intervention for Dementia Deterrence (In-MINDD) intervention into daily life and routine practice. In-MINDD is a multi-centre, primary care-based, single-blinded randomised controlled feasibility trial currently being conducted in four European countries (France, Ireland, the Netherlands and the UK). Participants are being recruited from participating general practices. Inclusion criteria will include age between 40 and 60 years; at least one modifiable risk factor for dementia risk (including diabetes, hypertension, obesity, renal dysfunction, current smoker, raised cholesterol, coronary heart disease, current or previous history of depression, self-reported sedentary lifestyle, and self-reported low cognitive activity) access to the Internet. Primary outcome measure will be a change in dementia risk modification score over the timescale of the trial (6 months). A qualitative process evaluation will interview a sample of participants and practitioners about their views on the acceptability and feasibility of the trial and the links between modifiable risk factors and dementia prevention. This work will be underpinned by Normalisation Process Theory. This study will explore the feasibility and acceptability of a risk profiler and on-line support environment to help individuals in mid-life assess their risk of developing dementia in later life and to take steps to alleviate that risk by tackling health-related behaviour change. Testing the intervention in a robust and theoretically informed manner will inform the development of a future, full-scale randomised controlled trial. ISRCTN Registry: ISRCTN 98553005 (DOI: 10.1186/ISRCTN98553005).
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Kate Irving, Kevin Power, Marjan van den Akker, Frans R J Verhey, Muriel Redmond, Sebastian Köhler, Valeria Manera, Martin P J van Boxtel, Kay Deckers, Alex McConnachie and 3 others

Experts in our system

1
Kate Irving
Dublin City University
Total Publications: 66
 
2
Frans Verhey
Dublin City University
Total Publications: 25
 
3
Sebastian Köhler
Dublin City University
Total Publications: 6
 
4
Martin P J van Boxtel
Dublin City University
Total Publications: 8
 
5
Kay Deckers
Dublin City University