Journal Article


Richard O'Kennedy
Julia Zapatero-Rodríguez
Shikha Sharma


Medicine & Nursing

diagnostics effective this review tools prostate cancer predictive accuracy prostate specific antigen clinical

Prostate cancer diagnostics: Clinical challenges and the ongoing need for disruptive and effective diagnostic tools. (2016)

Abstract The increased incidence and the significant health burden associated with carcinoma of the prostate have led to substantial changes in its diagnosis over the past century. Despite technological advancements, the management of prostate cancer has become progressively more complex and controversial for both early and late-stage disease. The limitations and potential harms associated with the use of prostate-specific antigen (PSA) as a diagnostic marker have stimulated significant investigation of numerous novel biomarkers that demonstrate varying capacities to detect prostate cancer and can decrease unnecessary biopsies. However, only a few of these markers have been approved for specific clinical settings while the others have not been adequately validated for use. This review systematically and critically assesses ongoing issues and emerging challenges in the current state of prostate cancer diagnostic tools and the need for disruptive next generation tools based on analysis of combinations of these biomarkers to enhance predictive accuracy which will benefit clinical diagnostics and patient welfare.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

Richard O'Kennedy, Julia Zapatero-Rodríguez, Shikha Sharma

Experts in our system

R O'Kennedy
Dublin City University
Total Publications: 197
Julia Zapatero-Rodríguez
Dublin City University
Total Publications: 6
Shikha Sharma
Dublin City University
Total Publications: 10