Type

Journal Article

Authors

Liam Cormican
John Faul
Aisling McGowan
Jessica Bramham
Katrina Hutchinson
Conor P Kerley

Subjects

Physiotherapy & Sport

Topics
glucose tolerance test body mass index quality of life trail making test vitamin d vitamin d supplementation vitamin d deficiency randomized controlled trial

Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study. (2016)

Abstract Our group and others have reported a high rate of vitamin D deficiency in obstructive sleep apnea (OSA), where vitamin D levels (25(OH) D) correlate negatively with OSA severity and some of its associated metabolic alterations. Data regarding vitamin D supplementation in OSA are lacking. We wanted to evaluate the effect of vitamin D3 supplementation on OSA symptoms and metabolic parameters. We conducted a pilot, double-blind, randomized, placebo-controlled trial of daily supplementation with 4,000 IU vitamin D3 (D3) or placebo (PL). We studied 19 Caucasian adults (14 male, mean age 55 y, mean body mass index [BMI] 30.4 kg/m(2)) with OSA. Fifteen patients were stable on continuous positive airways pressure (CPAP) therapy, whereas four were CPAP naïve. Assessments were completed at baseline and after 15 weeks of supplementation. Outcomes included sleepiness (Epworth Sleepiness Scale), quality of life (Sleep Apnea Quality of Life Inventory), fatigue (fatigue severity scale) and neuropsychological function (trail making test and Connor's Continuous Performance Test II). In addition, we assessed biochemical indices of vitamin D status (25(OH)D, calcium), inflammation (high sensitivity C-reactive protein, and lipoprotein-associated phospholipase A2), lipids (total cholesterol [low-density and high-density lipoprotein]) and glycemic indices (fasting glucose, oral glucose tolerance test). There was no change in BMI, medication, or CPAP usage. Although there was no change in neuropsychological or quality of life indices, we observed a significant increase in 25(OH)D (p = 0.00001) and significant decreases in both low-density lipoprotein (p = 0.04) and lipoprotein-associated phospholipase A2 (p = 0.037) as well as trends toward decreased fasting glucose (p = 0.09) and increased high-density lipoprotein (p = 0.07) in the D3 group compared to PL. Vitamin D3 supplementation increased vitamin D levels and decreased metabolic markers compared to placebo. Larger trials are required.
Collections Ireland -> IT Blanchardstown -> PubMed

Full list of authors on original publication

Liam Cormican, John Faul, Aisling McGowan, Jessica Bramham, Katrina Hutchinson, Conor P Kerley

Experts in our system

1
Liam Cormican
IT Blanchardstown
 
2
John Faul
IT Blanchardstown
Total Publications: 11
 
3
Aisling McGowan
IT Blanchardstown
Total Publications: 3
 
4
Katrina Hutchinson
IT Blanchardstown
 
5
Conor P Kerley
IT Blanchardstown