Type

Journal Article

Authors

Arun L W Bokde
Paul Mullins
Jonathan P McNulty
Desmond O'Neill
Christian Kerskens
Dervla Farrell
Elizabeth G Kehoe
Francesca Sibilia

Subjects

Psychology

Topics
memory aging young adults diffusion imaging network 5 years groups older adults

Aging-Related Microstructural Alterations Along the Length of the Cingulum Bundle. (2017)

Abstract The aim of this study was to investigate the aging-related structural changes of the cingulum, one of the major components of the limbic network, which has a critical role in emotion, attention, and memory. Thirty-five healthy young adults (22.3 ± 2.7 years) and 33 healthy older adults (69.5 ± 3.5 years) were recruited. Diffusion weighted imaging data were acquired with a b-value = 2000 sec/mm(2) and 61 diffusion directions and 4 non-weighted images. The fiber directions in each voxel were based on the constrained spherical deconvolution model. The cingulum was segmented into three branches using deterministic tractography (subgenual, retrosplenial, and parahippocampal), using a region-of-interest-based approach. Atlas-based tractography was the method used to obtain the output tracts of each branch of the cingulum. Along-tract analysis was performed on each branch. We found a statistically significant change with aging in the left subgenual branch of the cingulum with a decrease in fractional anisotropy and axial diffusivity, as well as an increase in radial diffusivity. No statistically significant differences were found between young and older groups in the other two branches. This study adds to knowledge about how the cingulum changes structurally along its entire length during aging in a more detailed way, thanks to an advanced methodological approach.
Collections Ireland -> TU Dublin (Tallaght Campus) -> PubMed

Full list of authors on original publication

Arun L W Bokde, Paul Mullins, Jonathan P McNulty, Desmond O'Neill, Christian Kerskens, Dervla Farrell, Elizabeth G Kehoe, Francesca Sibilia

Experts in our system

1
Arun L W Bokde
Trinity College Dublin
Total Publications: 144
 
2
Jonathan P McNulty
University College Dublin
Total Publications: 27
 
3
Desmond O'Neill
Trinity College Dublin
Total Publications: 140
 
4
Dervla Farrell
Trinity College Dublin
Total Publications: 4
 
5
Elizabeth G Kehoe
Trinity College Dublin
Total Publications: 13