Type

Journal Article

Authors

Eva M Jimenez-Mateos
Tobias Engel
Miguel Medina
Aidan Kenny
Sean Quinlan

Subjects

Psychiatry

Topics
gene expression novel targets traumatic brain injury status epilepticus neurodegenerative diseases this review neurodegenerative disorders neurological disorders

MicroRNAs in Neurodegenerative Diseases. (2017)

Abstract MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level in a sequence-specific manner. After their discovery in 1993, mounting data have provided compelling evidence for their causal involvement in several human diseases, such as cancer and disorders of the brain. MicroRNAs have been described as the main regulator of homeostasis in neurons, and their dysregulation results in pathological conditions in the brain. In this review, we will focus on the role of MicroRNAs as novel drug targets and biomarkers of the three main neurodegenerative disorders (Alzheimer's disease, Parkinson's diseases, and Huntington's disease) and their role in other neurological disorders including traumatic brain injury and status epilepticus.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Eva M Jimenez-Mateos, Tobias Engel, Miguel Medina, Aidan Kenny, Sean Quinlan

Experts in our system

1
Eva M Jimenez-Mateos
Royal College of Surgeons in Ireland
Total Publications: 55
 
2
Tobias Engel
Royal College of Surgeons in Ireland
Total Publications: 66
 
3
Aidan Kenny
Royal College of Surgeons in Ireland
Total Publications: 3
 
4
Sean Quinlan
Royal College of Surgeons in Ireland
Total Publications: 6