Journal Article


N G McElvaney
C Gunaratnam
A Franciosi
T McEnery
M E O'Brien
O O'Carroll
C McCarthy


Medicine & Nursing

cystic fibrosis statistical analysis candida albicans complications risk factors device adult venous thrombosis

Risk factors for totally implantable venous access device-associated complications in cystic fibrosis. (2017)

Abstract Candidaemia is an important nosocomial infection, seen frequently in immunocompromised and critically ill patients and increasingly recognised in cystic fibrosis (CF) patients with totally implantable venous access devices (TIVADs). This study aims to investigate the incidence and risk factors for the development of TIVAD-associated candidaemia and to assess the rate of TIVAD-related complications in CF patients. A 10-year retrospective study was carried out on adult CF patients attending a single centre. Complications were recorded including the incidence of candidaemia and correlated to clinical parameters. Complication rates were calculated based on incidence per 1000 catheter days. Statistical analysis was performed using Mann-Whitney U test and Fisher's exact test. Fourteen cases of candidaemia were observed in the CF cohort, primarily caused by Candida parapsilosis and Candida albicans. Candidaemia was associated with lower FEV1 (p = 0.0117) and higher frequency of pulmonary exacerbation (p < 0.0001). A TIVAD complication rate of 0.337/1000 catheter days was observed in the CF cohort. Complications included venous thrombosis, stenosis, and port extrusion; complications were independently associated with more frequent pulmonary exacerbations (p = 0.04). TIVAD complications are observed more commonly in those with lower FEV1 and frequent pulmonary exacerbations, suggesting that candidaemia may be related to antibiotic use and furthermore can occur following invasive procedures causing translocation of fungal species allowing transformation from colonisation to pathogenic infection.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

N G McElvaney, C Gunaratnam, A Franciosi, T McEnery, M E O'Brien, O O'Carroll, C McCarthy

Experts in our system

Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
Cedric Gunaratnam
Royal College of Surgeons in Ireland
Total Publications: 18
M Emmet O'Brien
Royal College of Surgeons in Ireland
Total Publications: 9
Cormac McCarthy
Royal College of Surgeons in Ireland
Total Publications: 19