Type

Journal Article

Authors

Daniel J Kelly
Jessica Nulty
Susan E Critchley
Tomas Gonzalez-Fernandez
Fiona E Freeman
Andrew C Daly

Subjects

Engineering

Topics
cartilage tissue architecture bone regeneration osteochondral tissue engineering bone tissue engineering adult technology soft tissue

3D Bioprinting for Cartilage and Osteochondral Tissue Engineering. (2017)

Abstract Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints will one day reach the clinic however, a number of major challenges must still be addressed before this becomes a reality. These include vascularization in the context of large bone defect repair, engineering complex gradients for bone-soft tissue interface regeneration and recapitulating the stratified zonal architecture present in many adult tissues such as articular cartilage. Tissue engineered constructs typically lack such spatial complexity in cell types and tissue organization, which may explain their relatively limited success to date. This has led to increased interest in bioprinting technologies in the field of musculoskeletal tissue engineering. The additive, layer by layer nature of such biofabrication strategies makes it possible to generate zonal distributions of cells, matrix and bioactive cues in 3D. The adoption of biofabrication technology in musculoskeletal tissue engineering may therefore make it possible to produce the next generation of biological implants capable of treating a range of conditions. Here, advances in bioprinting for cartilage and osteochondral tissue engineering are reviewed.
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Full list of authors on original publication

Daniel J Kelly, Jessica Nulty, Susan E Critchley, Tomas Gonzalez-Fernandez, Fiona E Freeman, Andrew C Daly

Experts in our system

1
Daniel Kelly
Trinity College Dublin
Total Publications: 168
 
2
Jessica Nulty
Royal College of Surgeons in Ireland
Total Publications: 3
 
3
Susan E Critchley
Royal College of Surgeons in Ireland
Total Publications: 3
 
4
Tomas Gonzalez-Fernandez
Trinity College Dublin
Total Publications: 5
 
5
Andrew C Daly
Trinity College Dublin
Total Publications: 9