Type

Journal Article

Authors

David R Cotter
Juana Maria Pasquini
Gerard Cagney
Mary Cannon
Michael Farrell
Kieran Wynne
Patrick Dicker
Analia Reines
Martin Codagnone
Melanie Focking
and 2 others

Subjects

Pharmacology

Topics
risperidone deficiency mass spectrometry treatment effects rat iron prenatal frontal cortex

The Effects of Prenatal Iron Deficiency and Risperidone Treatment on the Rat Frontal Cortex:  A Proteomic Analysis. (2016)

Abstract Prenatal iron deficiency (pID) has been described to increase the risk for neurodevelopmental disorders such as autism and schizophrenia; however, the precise molecular mechanisms are still unknown. Here, we utilized high throughput mass spectrometry to examine the proteomic effects of pID in adulthood on the rat frontal cortex area (FCA). In addition, the FCA proteome was examined in adulthood following risperidone treatment in adolescence to see if these effects could be prevented. We identified 1501 proteins of which 100 were significantly differentially expressed in the FCA at post-natal day 90. Pathway Analysis of proteins affected by pID revealed changes in metabolic processes, including the tricyclic acid cycle, mitochondrial dysfunction, and P13K/Akt signaling. Interestingly, most of these protein changes were not present in the adult pID offspring who received risperidone in adolescence. Considering the link between prenatal iron deficiency and several neurodevelopmental disorders such as autism and schizophrenia these presented results bring new perspectives to understand the role of iron in metabolic pathways and provide novel biomarkers for future studies of prenatal iron deficiency. This article is protected by copyright. All rights reserved.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

David R Cotter, Juana Maria Pasquini, Gerard Cagney, Mary Cannon, Michael Farrell, Kieran Wynne, Patrick Dicker, Analia Reines, Martin Codagnone, Melanie Focking and 2 others

Experts in our system

1
David R Cotter
Royal College of Surgeons in Ireland
Total Publications: 56
 
2
Gerard Cagney
Royal College of Surgeons in Ireland
Total Publications: 54
 
3
Mary Cannon
Royal College of Surgeons in Ireland
Total Publications: 90
 
4
Kieran Wynne
Royal College of Surgeons in Ireland
Total Publications: 45
 
5
Patrick Dicker
Royal College of Surgeons in Ireland
Total Publications: 95
 
6
Melanie Focking
Royal College of Surgeons in Ireland