Type

Journal Article

Authors

Noel G McElvaney
Emer P Reeves
Douglas J Veale
Ursula Fearon
Dermot Kenny
Geraldine McCarthy
Paul O'Connell
Eimear Dunne
David J L Hunt
Danielle M Dunlea
and 4 others

Subjects

Microbiology

Topics
genetics alpha 1 antitrypsin cyclic citrullinated peptide antibodies antinuclear polymorphism genetic peptides cyclic mutation alpha 1 antitrypsin deficiency epidemiology case control studies autoantibodies humans arthritis rheumatoid prevalence genotype rheumatoid factor phenotype immunology

Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis. (2017)

Abstract To examine the prevalence of α1 -antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANAs), and anti-citrullinated peptide autoantibodies (ACPAs). RF, ANAs, and ACPAs were measured by standard immunoturbidimetry, immunofluorescence assay, and enzyme-linked immunosorbent assay, respectively. Characterization of AAT phenotypes was performed by isoelectric focusing and immunofixation. The chi-square test with Yates' correction and the Mann-Whitney U test were used to assess the prevalence of alleles associated with AATD in RA and to compare mean antibody titers, respectively. Of 246 patients with RA, 24 who were heterozygous for AATD were identified, with no statistically significant difference in the prevalence of AATD between RA patients and the general population (P = 0.39). A positive association between heterozygosity for AATD and the production of ACPAs was observed (P < 0.0001), with increased ACPA titers recorded in the AATD RA cohort compared with the general population (P = 0.01). AAT heterozygous status in RA is strongly associated with positive ACPAs and may define a distinct subset of patients with increased disease severity.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Noel G McElvaney, Emer P Reeves, Douglas J Veale, Ursula Fearon, Dermot Kenny, Geraldine McCarthy, Paul O'Connell, Eimear Dunne, David J L Hunt, Danielle M Dunlea and 4 others

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
2
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63
 
3
Douglas J Veale
Trinity College Dublin
 
4
Ursula Fearon
Trinity College Dublin
 
5
Dermot Kenny
Royal College of Surgeons in Ireland
 
6
Geraldine M McCarthy
University College Dublin
Total Publications: 38
 
7
Paul O'Connell
Royal College of Surgeons in Ireland
Total Publications: 4
 
8
Eimear Dunne
Royal College of Surgeons in Ireland
Total Publications: 19
 
9
Danielle M Dunlea
Royal College of Surgeons in Ireland
Total Publications: 6