Type

Journal Article

Authors

Richard W Costello
Richard B Reilly
Fiona Boland
Aoife Sartini Bhreathnach
Matshediso Constantina Mokoka
Breda Cushen
Spiros Giannoutsos
Isabelle Killane
Elaine MacHale
Nirmal Sadasivuni
and 2 others

Subjects

Pharmacology

Topics
prospective study drug errors critical phase drug delivery flow patients blood

The Impact of Common Inhaler Errors on Drug Delivery: Investigating Critical Errors with a Dry Powder Inhaler. (2017)

Abstract Researchers, using checklists, have identified that 30%-90% of patients make errors in inhaler use. It is not certain whether these errors affect the delivery of medication. We have developed an electronic monitor (INCA™) that records audio each time an inhaler is used, providing objective information on inhaler technique. The aim of this study was to assess the effect that correctly identified inhaler errors, with the INCA device, have on drug delivery. This was a prospective study of healthy volunteers using a salbutamol Diskus™. The inclusion criteria allowed for the recruitment of healthy participants who were nonfrequent users of Salbutamol. Each participant was assigned to one control "phase" first and two/three subsequent error "phases." Each phase consisted of six doses of the drug taken 6 hours apart, and the participants' blood was drawn before and 25 minutes after doses one and six. This allowed us to sample their trough and peak serum salbutamol levels. Fourteen healthy volunteers were studied. The inhaler technique errors simulated in this study included exhaling into the device after drug priming but before inhalation, low inspiratory flow, multiple inhalations, low breath hold, missed doses, and wrong inhaler position. Only the exhalation error, low inspiratory flow, and missed doses led to a significant reduction in serum salbutamol levels. After six doses of the exhalation error, there was a 62% reduction in peak salbutamol levels. Low inspiratory flow led to a 52% reduction in peak salbutamol levels and a 78% reduction in trough levels. Missed doses led to a 37% reduction in trough salbutamol levels. These findings confirm that technique errors affect drug delivery. Furthermore, we were able to identify that the most critical technique errors with the Diskus inhaler are exhalation into the device before inhalation, poor inspiratory flow, and missing doses.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Richard W Costello, Richard B Reilly, Fiona Boland, Aoife Sartini Bhreathnach, Matshediso Constantina Mokoka, Breda Cushen, Spiros Giannoutsos, Isabelle Killane, Elaine MacHale, Nirmal Sadasivuni and 2 others

Experts in our system

1
Richard W Costello
Royal College of Surgeons in Ireland
Total Publications: 66
 
2
Richard Reilly
Trinity College Dublin
Total Publications: 185
 
3
Fiona Boland
Royal College of Surgeons in Ireland
Total Publications: 52
 
4
Aoife Sartini Bhreathnach
Royal College of Surgeons in Ireland
Total Publications: 4
 
5
Matshediso Mokoka
Royal College of Surgeons in Ireland
Total Publications: 7
 
6
Breda Cushen
Royal College of Surgeons in Ireland
Total Publications: 13
 
7
Isabelle Killane
Royal College of Surgeons in Ireland
Total Publications: 12
 
8
Elaine MacHale
Royal College of Surgeons in Ireland
Total Publications: 19