Type

Journal Article

Authors

David C Henshall
Gary P Brennan

Subjects

Biochemistry

Topics
epilepsy temporal lobe processes acid micrornas technology pathophysiology gene expression regulation epilepsy

microRNAs in the pathophysiology of epilepsy. (2016)

Abstract Temporal lobe epilepsy is a common and often drug-resistant seizure disorder. The underlying pathological processes which give rise to the development of spontaneous seizures include neuroinflammation, cell loss, neurogenesis and dendritic abnormalities and many of these are driven by insult-induced changes in gene expression and gene expression regulation. MicroRNAs are powerful modulators of post-transcriptional gene expression which are dysregulated during epileptogenesis. The advent of locked nucleic acid (LNA) based inhibitory methods and mimic technology has facilitated in vivo functional assessment of these molecules in epilepsy. Here we review recent advances in our understanding of the role of these short non-coding RNAs in the pathophysiology of epilepsy.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

David C Henshall, Gary P Brennan

Experts in our system

1
David C Henshall
Royal College of Surgeons in Ireland
Total Publications: 127
 
2
Gary P Brennan
Royal College of Surgeons in Ireland
Total Publications: 14