Type

Journal Article

Authors

Song Miao
Catherine Stanton
Hongzhou Zhang
Pierce Maguire
Alan L Kelly
Wei Lu

Subjects

Biology

Topics
cellular uptake behavior size structure whey protein caco 2 cell culture droplet size influence

Correlation of Emulsion Structure with Cellular Uptake Behavior of Encapsulated Bioactive Nutrients: Influence of Droplet Size and Interfacial Structure. (2016)

Abstract In this study, an in vitro Caco-2 cell culture assay was employed to evaluate the correlation between emulsion structure and cellular uptake of encapsulated β-carotene. After 4 h of incubation, an emulsion stabilized with whey protein isolate showed the highest intracellular accumulation of β-carotene (1.06 μg), followed by that stabilized with sodium caseinate (0.60 μg) and Tween 80 (0.20 μg), which are 13-, 7.5-, and 2.5-fold higher than that of free β-carotene (0.08 μg), respectively. Emulsions with small droplet size (239 ± 5 nm) showed a higher cellular uptake of β-carotene (1.56 μg) than emulsiond with large droplet size (489 ± 9 nm) (0.93 μg) (p < 0.01). The results suggested that delivery in an emulsion significantly improved the cellular uptake of β-carotene and thus potentially its bioavailability; uptake was closely correlated with the interfacial composition and droplet size of emulsions. The findings support the potential for achieving optimal controlled and targeted delivery of bioactive nutrients by structuring emulsions.
Collections Ireland -> Teagasc -> PubMed

Full list of authors on original publication

Song Miao, Catherine Stanton, Hongzhou Zhang, Pierce Maguire, Alan L Kelly, Wei Lu

Experts in our system

1
Song Miao
Teagasc
Total Publications: 28
 
2
Catherine Stanton
Teagasc
Total Publications: 267
 
3
Alan L. Kelly
Teagasc
Total Publications: 63
 
4
Wei Lu
Teagasc
Total Publications: 7