Journal Article


Brian Lawlor
Gunhild Waldemar
Bengt Winblad
Pieter Jelle Visser
Charlotte E Teunissen
Philip Scheltens
Aleksandra Rutkowska
Mary Gardiner
Kaj Blennow
Mircea Balasa
and 1 others



cognitive impairment cerebrospinal fluid diagnostic use europe clinical practice approaches reference values diagnosis differential

Current Approaches and Clinician Attitudes to the Use of Cerebrospinal Fluid Biomarkers in Diagnostic Evaluation of Dementia in Europe. (2017)

Abstract BIOMARKAPD seeks to diminish the barriers associated with the clinical use of cerebrospinal fluid (CSF) biomarker analysis by reducing variation in CSF laboratory methodologies and generating consensus recommendations on their clinical interpretation and application for dementia diagnosis. To examine the disparity in practitioner attitudes and clinical practice relating to the use of CSF biomarkers for dementia diagnosis across Europe. Clinical dementia experts were surveyed on the prevalence of national consensus guidelines and analytical reimbursement across Europe; their biomarker platform preferences, lumbar puncture methodologies, and application of reference values and cut-offs for CSF analysis. 74% of respondents (total nā€Š=ā€Š51) use CSF biomarkers in clinical practice and 69% performed lumbar punctures on an outpatient basis. Most use CSF biomarkers to diagnose atypical (84%) and early onset cases of cognitive impairment (71%) and for the differential diagnosis of other dementias (69%). 82% state they are sufficiently informed about CSF biomarkers yet 61% report a lack of national consensus guidelines on their use for dementia diagnosis. 48% of countries represented do not reimburse clinical CSF analysis. 43% report using normal reference ranges derived from publications. Variations in attitude and practice relating to CSF biomarkers, widely recognized as barriers to their clinical acceptance, remain evident within and between countries across Europe, even in expert centers. These shortcomings must be addressed by developing consensus guidelines on CSF-related methodologies and their clinical application to further their use for the diagnostic evaluation of dementia.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Brian Lawlor, Gunhild Waldemar, Bengt Winblad, Pieter Jelle Visser, Charlotte E Teunissen, Philip Scheltens, Aleksandra Rutkowska, Mary Gardiner, Kaj Blennow, Mircea Balasa and 1 others

Experts in our system

Brian A. Lawlor
National College Ireland
Total Publications: 125
Aleksandra Rutkowska
Trinity College Dublin
Total Publications: 3
Kaj Blennow
Trinity College Dublin
Total Publications: 8