Type

Journal Article

Authors

Shigeki Nakagome
Aiden Corvin
Claire Foley

Subjects

Psychiatry

Topics
drug discovery meta analysis genetics large scale genome sequencing this review patient care genome wide association studies

Genetics of Schizophrenia: Ready to Translate? (2017)

Abstract This is an era where we have significantly advanced the understanding of the genetic architecture of schizophrenia. In this review, we consider how this knowledge may translate into advances that will improve patient care. Large-scale genome-wide association studies (GWAS) have identified more than a hundred loci each making a small contribution to illness risk. Meta-analysis of copy number variants (CNVs) in the Psychiatric Genomics Consortium (PGC) dataset has confirmed that some variants have a moderate or large impact on risk, although these are rare in the population. Genome sequencing advances allow a much more comprehensive evaluation of genomic variation. We describe the key findings from whole exome studies to date. These studies are happening against a backdrop of growing understanding of the regulation and expression of genes and better functional tools to investigate molecular mechanisms in model systems. We provide an overview of how recent approaches in schizophrenia genetics are converging and consider how they could impact on diagnostics, the development of personalized medicine, and drug discovery.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Shigeki Nakagome, Aiden Corvin, Claire Foley

Experts in our system

1
Shigeki Nakagome
Trinity College Dublin
Total Publications: 7
 
2
Aiden Corvin
Trinity College Dublin
Total Publications: 199