Type

Journal Article

Authors

Michelle E Kelly
Brian A Lawlor
Sabina Brennan
Sara Lavecchia
David G Loughrey

Subjects

Psychiatry

Topics
this review meta analysis randomized controlled trials longitudinal studies cohort studies cognitive psychology impact analysis systematic review older adults cognition welfare of older people

The Impact of the Mediterranean Diet on the Cognitive Functioning of Healthy Older Adults: A Systematic Review and Meta-Analysis. (2017)

Abstract Evidence from epidemiologic studies suggests a relation between the Mediterranean diet (MeDi) and cognitive function, but results are inconsistent. Prior reviews have not provided pooled data from meta-analysis of longitudinal studies and randomized controlled trials (RCTs), or they included younger adult participants. This systematic review and meta-analysis examines the impact of the MeDi on the cognitive functioning of healthy older adults. Fifteen cohort studies with 41,492 participants and 2 RCTs with 309 and 162 participants in intervention and control groups, respectively, were included. The primary outcome of interest was cognitive function, divided into domains of memory and executive function. Meta-analysis of cohort studies revealed a significant association between MeDi and older adults' episodic memory (n = 25,369, r = 0.01, P = 0.03) and global cognition (n = 41,492, r = 0.05, P ≤ 0.001), but not working memory (n = 1487, r = 0.007, P = 0.93) or semantic memory (n = 1487, r = 0.08, P = 0.28). Meta-analysis of RCTs revealed that compared with controls, the MeDi improved delayed recall (n = 429, P = 0.01), working memory (n = 566, P = 0.03), and global cognition (n = 429, P = 0.047), but not episodic memory (n = 566, P = 0.15), immediate recall (n = 566, P = 0.17), paired associates (n = 429, P = 0.20), attention (n = 566, P = 0.69), processing speed (n = 566, P = 0.35), or verbal fluency (n = 566, P = 0.12). The strongest evidence suggests a beneficial effect of the MeDi on older adults' global cognition. This article discusses the influence of study design and components of the MeDi on cognitive function and considers possible mechanisms.
Collections Ireland -> National College Ireland -> Status = Published
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognitive psychology
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion
Ireland -> Trinity College Dublin -> PubMed
Ireland -> National College Ireland -> Subject = H Social Sciences
Ireland -> National College Ireland -> Subject = H Social Sciences: HV Social pathology. Social and public welfare
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Research Institutes: Human Health Institute
Ireland -> Maynooth University -> Status = Published
Ireland -> Maynooth University -> Open Access DRIVERset
Ireland -> National College Ireland -> Subject = B Philosophy. Psychology. Religion: Psychology: Cognition
Ireland -> National College Ireland -> Subject = H Social Sciences: HV Social pathology. Social and public welfare: Welfare of older people
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering: Research Institutes
Ireland -> Maynooth University -> Type = Article
Ireland -> Maynooth University -> Academic Unit = Faculty of Science and Engineering
Ireland -> National College Ireland -> Type = Article

Full list of authors on original publication

Michelle E Kelly, Brian A Lawlor, Sabina Brennan, Sara Lavecchia, David G Loughrey

Experts in our system

1
Michelle E Kelly
National College Ireland
Total Publications: 51
 
2
Brian A. Lawlor
National College Ireland
Total Publications: 125
 
3
Sabina Brennan
National College Ireland
Total Publications: 47
 
4
David G Loughrey
National College Ireland
Total Publications: 12