Type

Journal Article

Authors

Sylvane Desrivieres
Gunter Schumann
Robert Whelan
Henrik Walter
Michael N Smolka
Luise Poustka
Tomas Paus
Dimitri Papadopoulos Orfanos
Frauke Nees
Marie-Laure Paillère Martinot
and 17 others

Subjects

Psychiatry

Topics
functional magnetic resonance imaging attention deficit disorder with hyperactivity neural mechanisms response inhibition year 1 genetic variation attention deficit hyperactivity disorder adhd association study

Impact of a Common Genetic Variation Associated With Putamen Volume on Neural Mechanisms of Attention-Deficit/Hyperactivity Disorder. (2016)

Abstract In a recent genomewide association study of subcortical brain volumes, a common genetic variation at rs945270 was identified as having the strongest effect on putamen volume, a brain measurement linked to familial risk for attention-deficit/hyperactivity disorder (ADHD). To determine whether rs945270 might be a genetic determinant of ADHD, its effects on ADHD-related symptoms and neural mechanisms of ADHD, such as response inhibition and reward sensitivity, were explored. A large population sample of 1,834 14-year-old adolescents was used to test the effects of rs945270 on ADHD symptoms assessed through the Strengths and Difficulties Questionnaire and region-of-interest analyses of putamen activation by functional magnetic resonance imaging using the stop signal and monetary incentive delay tasks, assessing response inhibition and reward sensitivity, respectively. There was a significant link between rs945270 and ADHD symptom scores, with the C allele associated with lower symptom scores, most notably hyperactivity. In addition, there were sex-specific effects of this variant on the brain. In boys, the C allele was associated with lower putamen activity during successful response inhibition, a brain response that was not associated with ADHD symptoms. In girls, putamen activation during reward anticipation increased with the number of C alleles, most significantly in the right putamen. Remarkably, right putamen activation during reward anticipation tended to negatively correlate with ADHD symptoms. These results indicate that rs945270 might contribute to the genetic risk of ADHD partly through its effects on hyperactivity and reward processing in girls.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Sylvane Desrivieres, Gunter Schumann, Robert Whelan, Henrik Walter, Michael N Smolka, Luise Poustka, Tomas Paus, Dimitri Papadopoulos Orfanos, Frauke Nees, Marie-Laure Paillère Martinot and 17 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
2
Robert Whelan
Trinity College Dublin
Total Publications: 80
 
3
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
4
Tomas Paus
Trinity College Dublin
Total Publications: 62
 
5
Frauke Nees
Trinity College Dublin
Total Publications: 63