Type

Journal Article

Authors

Jianfeng Feng
Gunter Schumann
Robert Whelan
Henrik Walter
Michael N Smolka
Luise Poustka
Dimitri Papadopoulos Orfanos
Frauke Nees
Hervé Lemaitre
Jean-Luc Martinot
and 17 others

Subjects

Psychology

Topics
big data human failure dorsolateral prefrontal cortex emotional neural inhibition anterior cingulate functional connectivity

Separate neural systems for behavioral change and for emotional responses to failure during behavioral inhibition. (2017)

Abstract To analyze the involvement of different brain regions in behavioral inhibition and impulsiveness, differences in activation were investigated in fMRI data from a response inhibition task, the stop-signal task, in 1709 participants. First, areas activated more in stop-success (SS) than stop-failure (SF) included the lateral orbitofrontal cortex (OFC) extending into the inferior frontal gyrus (ventrolateral prefrontal cortex, BA 47/12), and the dorsolateral prefrontal cortex (DLPFC). Second, the anterior cingulate and anterior insula (AI) were activated more on failure trials, specifically in SF versus SS. The interaction between brain region and SS versus SF activations was significant (P = 5.6 * 10(-8) ). The results provide new evidence from this "big data" investigation consistent with the hypotheses that the lateral OFC is involved in the stop-related processing that inhibits the action; that the DLPFC is involved in attentional processes that influence task performance; and that the AI and anterior cingulate are involved in emotional processes when failure occurs. The investigation thus emphasizes the role of the human lateral OFC BA 47/12 in changing behavior, and inhibiting behavior when necessary. A very similar area in BA47/12 is involved in changing behavior when an expected reward is not obtained, and has been shown to have high functional connectivity in depression. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Jianfeng Feng, Gunter Schumann, Robert Whelan, Henrik Walter, Michael N Smolka, Luise Poustka, Dimitri Papadopoulos Orfanos, Frauke Nees, Hervé Lemaitre, Jean-Luc Martinot and 17 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
2
Robert Whelan
Trinity College Dublin
Total Publications: 80
 
3
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
4
Frauke Nees
Trinity College Dublin
Total Publications: 63
 
5
Jean-Luc Martinot
Trinity College Dublin
Total Publications: 54