Type

Journal Article

Authors

Jan H Veldink
Orla Hardiman
Jurjen J Luykx
Leonard H van den Berg
Ammar Al-Chalabi
Daniel G Bradley
An Goris
Roel A Ophoff
René S Kahn
Margaret O'Brien
and 4 others

Subjects

Psychiatry

Topics
future genetic schizophrenia genome wide association study odds ratio amyotrophic lateral sclerosis false discovery rate linkage disequilibrium

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. (2016)

Abstract We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Jan H Veldink, Orla Hardiman, Jurjen J Luykx, Leonard H van den Berg, Ammar Al-Chalabi, Daniel G Bradley, An Goris, Roel A Ophoff, René S Kahn, Margaret O'Brien and 4 others

Experts in our system

1
Jan H Veldink
Trinity College Dublin
Total Publications: 13
 
2
Orla Hardiman
Trinity College Dublin
Total Publications: 156
 
3
Leonard H van den Berg
Trinity College Dublin
Total Publications: 19
 
4
Ammar Al-Chalabi
Trinity College Dublin
Total Publications: 20
 
5
Daniel Bradley
Trinity College Dublin
Total Publications: 84
 
6
Roel A Ophoff
Trinity College Dublin
Total Publications: 12
 
7
Margaret O'Brien
National University of Ireland Galway
Total Publications: 20