Journal Article


S Norris
C Walsh
S Stewart
G Sheehan
F Murray
C McNally
S McKiernan
A McCormick
S McConkey
Pwg Mallon
and 13 others



treatment therapy effectiveness patients irish hepatitis c virus hcv interferon free

Effectiveness of interferon-free therapy for the treatment of HCV-patients with compensated cirrhosis treated through the Irish early access program. (2017)

Abstract We investigated the real-world effectiveness of interferon-free regimens for the treatment of patients with compensated cirrhosis infected with hepatitis C virus (HCV). Using the Irish national HCV treatment registry, the effectiveness and safety of interferon-free regimens for HCV-infected patients treated between April 2015 and August 2016, was determined. A SVR12 was achieved in 86% of subjects treated with sofosbuvir/ledipasvir ± ribavirin (SOF/LDV±RBV), 93% treated with paritaprevir, ombitasvir and ritonavir combined with dasabuvir ± ribavirin (3D±RBV) and 89% treated with sofosbuvir/daclatasvir ± ribavirin (SOF/DCV±RBV). The discontinuation rate was 5% and the on-treatment mortality rate was 1%. The availability of interferon-free regimens represents a significant breakthrough for the treatment of HCV infection. Treatments options, with high SVR12 rates, are now available for patients with compensated cirrhosis who were unsuitable for treatment with interferon-based regimens. Data obtained from studies conducted in real world practice provide robust information fundamental for input into future economic evaluations for agents used for the treatment of HCV infection.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

S Norris, C Walsh, S Stewart, G Sheehan, F Murray, C McNally, S McKiernan, A McCormick, S McConkey, Pwg Mallon and 13 others

Experts in our system

Suzanne Norris
Trinity College Dublin
Total Publications: 20
Cathal Walsh
University of Limerick
Total Publications: 109
Gerard Sheehan
Maynooth University
Total Publications: 15
F E Murray
Royal College of Surgeons in Ireland
Susan Mckiernan
Trinity College Dublin
Total Publications: 11
Samuel McConkey
Royal College of Surgeons in Ireland
Total Publications: 16