Type

Journal Article

Authors

David N Stephens
Gunter Schumann
Michael Smolka
Trevor W Robbins
Marcella Rietschel
Tomas Paus
Jean-Luc Martinot
Penny Gowland
Tianye Jia
Andreas Heinz
and 11 others

Subjects

Psychiatry

Topics
drug abuse brain function functional magnetic resonance imaging brain performance measures single human behavior addictive

GABRB1 Single Nucleotide Polymorphism Associated with Altered Brain Responses (but not Performance) during Measures of Impulsivity and Reward Sensitivity in Human Adolescents. (2016)

Abstract Variations in genes encoding several GABAA receptors have been associated with human drug and alcohol abuse. Among these, a number of human studies have suggested an association between GABRB1, the gene encoding GABAA receptor β1 subunits, with Alcohol dependence (AD), both on its own and comorbid with other substance dependence and psychiatric illnesses. In the present study, we hypothesized that the GABRB1 genetically-associated increased risk for developing alcoholism may be associated with impaired behavioral control and altered sensitivity to reward, as a consequence of altered brain function. Exploiting the IMAGEN database (Schumann et al., 2010), we explored in a human adolescent population whether possession of the minor (T) variant of the single nucleotide polymorphism (SNP) rs2044081 is associated with performance of tasks measuring aspects of impulsivity, and reward sensitivity that are implicated in drug and alcohol abuse. Allelic variation did not associate with altered performance in either a stop-signal task (SST), measuring one aspect of impulsivity, or a monetary incentive delay (MID) task assessing reward anticipation. However, increased functional magnetic resonance imaging (fMRI) blood-oxygen-level dependent (BOLD) response in the right hemisphere inferior frontal gyrus (IFG), left hemisphere caudate/insula and left hemisphere inferior temporal gyrus (ITG) during MID performance was higher in the minor (T) allelic group. In contrast, during SST performance, the BOLD response found in the right hemisphere supramarginal gyrus, right hemisphere lingual and left hemisphere inferior parietal gyrus indicated reduced responses in the minor genotype. We suggest that β1-containing GABAA receptors may play a role in excitability of brain regions important in controlling reward-related behavior, which may contribute to susceptibility to addictive behavior.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

David N Stephens, Gunter Schumann, Michael Smolka, Trevor W Robbins, Marcella Rietschel, Tomas Paus, Jean-Luc Martinot, Penny Gowland, Tianye Jia, Andreas Heinz and 11 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 55
 
2
Michael N Smolka
Trinity College Dublin
Total Publications: 56
 
3
Trevor W Robbins
Trinity College Dublin
Total Publications: 24
 
4
Marcella Rietschel
Trinity College Dublin
Total Publications: 39
 
5
Tomas Paus
Trinity College Dublin
Total Publications: 56
 
6
Jean-Luc Martinot
Trinity College Dublin
Total Publications: 45
 
7
Andreas Heinz
Trinity College Dublin
Total Publications: 55