Type

Journal Article

Authors

Brian Knutson
Gunter Schumann
Juergen Gallinat
Michael N Smolka
Trevor W Robbins
Marcella Rietschel
Luise Poustka
Zdenka Pausova
Tomas Paus
Frauke Nees
and 16 others

Subjects

Psychiatry

Topics
dorsolateral prefrontal cortex drug abuse behaviour future age adolescents drug use innovation

Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. (2015)

Abstract Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Brian Knutson, Gunter Schumann, Juergen Gallinat, Michael N Smolka, Trevor W Robbins, Marcella Rietschel, Luise Poustka, Zdenka Pausova, Tomas Paus, Frauke Nees and 16 others

Experts in our system

1
Gunter Schumann
Trinity College Dublin
Total Publications: 65
 
2
Michael N Smolka
Trinity College Dublin
Total Publications: 65
 
3
Trevor W Robbins
Trinity College Dublin
Total Publications: 25
 
4
Marcella Rietschel
Trinity College Dublin
Total Publications: 40
 
5
Tomas Paus
Trinity College Dublin
Total Publications: 62
 
6
Frauke Nees
Trinity College Dublin
Total Publications: 63