Journal Article


C McGuigan
S O'Riordan
N Tubridy
R Killeen
D Murphy
D J H McCabe
J Jones
L Williams
K O'Connell



irish population cauda equina treatment diagnosis differential cranial nerves spinal cord white matter patterns

Neurosarcoidosis: clinical presentations and changing treatment patterns in an Irish Caucasian population. (2016)

Abstract The clinical manifestations of neurosarcoidosis are highly variable and it should be considered as a potential differential diagnosis in any neurological presentation. This study was designed to describe the clinical, diagnostic, and treatment patterns and functional outcome in a Caucasian neurosarcoidosis population. A retrospective analysis was performed on prospectively recorded data in patients attending our neurology clinic between 2008 and 2014 with a diagnosis of definite or probable neurosarcoidosis according to Zajiek criteria. Detailed clinical features, baseline demographic data, results of investigations, treatment type and duration, and clinical outcomes were collated. Eleven patients were identified (55% men) with mean age 39 years (range 21-63). Four had a prior history of systemic sarcoidosis leading to earlier diagnosis (6.7 vs 13.1 months). Six were found to have evidence of systemic sarcoidosis on further investigation and one was biopsy proven isolated neurosarcoidosis. The commonest site of CNS involvement was the cranial nerves (64%), and headache (45%) was the most frequent presenting symptom. MRI abnormalities included leptomeningeal enhancement, white matter lesions, acute arteritis, spinal cord lesion, and cauda equina enhancement. The commonest CSF finding was raised protein (n = 6) and a lymphocytic pleocytosis (n = 7). Serum ACE was only elevated in three cases. Ten patients were treated with both corticosteroids and steroid-sparing agents 8 of whom went into remission. This series highlights the diverse nature of neurosarcoidosis. Early introduction of aggressive therapy with corticosteroids and steroid-sparing agents appears to improve clinical outcome.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

C McGuigan, S O'Riordan, N Tubridy, R Killeen, D Murphy, D J H McCabe, J Jones, L Williams, K O'Connell

Experts in our system

Christopher McGuigan
University College Dublin
Total Publications: 16
Niall Tubridy
University College Dublin
Total Publications: 24
Desmond M. Murphy
University College Cork
Total Publications: 30
Dominick J H McCabe
Trinity College Dublin
Total Publications: 43
J F X Jones
University College Dublin
Total Publications: 56
Laura Williams
Trinity College Dublin
Total Publications: 18
Karen O'Connell
University College Dublin
Total Publications: 11