Type

Journal Article

Authors

John V Reynolds
Jacintha O'Sullivan
Joanne Lysaght
Claire L Donohoe

Subjects

Medicine & Nursing

Topics
obesity genomic instability 5 years epithelial mesenchymal transition emt stromal cells concepts tumour microenvironment cancer

Emerging Concepts Linking Obesity with the Hallmarks of Cancer. (2016)

Abstract There is compelling epidemiological evidence linking obesity to many tumours; however, the molecular mechanisms fuelling this association are not clearly understood. Emerging evidence links changes in the tumour microenvironment with the obese state, and murine and human studies highlight the relevance of adipose stromal cells (ASCs), including immune cells, both at remote fat depots, such as the omentum, as well as in peritumoural tissue. These obesity-associated changes have been implicated in several hallmarks of cancer, including the chronic inflammatory state and associated cell signalling, epithelial-to-mesenchymal transition (EMT), tumour-related fibrosis, angiogenesis, and genomic instability. Here, we present a summary of developments over the past 5 years, with particular focus on the tumour microenvironment in the obese state.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

John V Reynolds, Jacintha O'Sullivan, Joanne Lysaght, Claire L Donohoe

Experts in our system

1
J V Reynolds
Trinity College Dublin
Total Publications: 206
 
2
Jacintha O'Sullivan
Trinity College Dublin
Total Publications: 74
 
3
Joanne Lysaght
Trinity College Dublin
Total Publications: 39
 
4
Claire L Donohoe
Trinity College Dublin
Total Publications: 38