Journal Article


Alessandro Serretti
Dan Rujescu
Julien Mendlewicz
Sven Cichon
Florence Thibaut
David St Clair
YongYong Shi
Peter Propping
Jorge Ospina-Duque
Michael C O'Donovan
and 21 others



protein expression socio economic gene expression diagnostic tests sensitivity and specificity clinical applications major depressive disorder mdd cost benefit

Consensus paper of the WFSBP Task Force on Genetics: Genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response. (2016)

Abstract Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-economic burden. Antidepressants of different classes are prescribed to treat MDD, but reliable and reproducible markers of efficacy are not available for clinical use. Further complicating treatment, the diagnosis of MDD is not guided by objective criteria, resulting in the risk of under- or overtreatment. A number of markers of MDD and antidepressant response have been investigated at the genetic, epigenetic, gene expression and protein levels. Polymorphisms in genes involved in antidepressant metabolism (cytochrome P450 isoenzymes), antidepressant transport (ABCB1), glucocorticoid signalling (FKBP5) and serotonin neurotransmission (SLC6A4 and HTR2A) were among those included in the first pharmacogenetic assays that have been tested for clinical applicability. The results of these investigations were encouraging when examining patient-outcome improvement. Furthermore, a nine-serum biomarker panel (including BDNF, cortisol and soluble TNF-α receptor type II) showed good sensitivity and specificity in differentiating between MDD and healthy controls. These first diagnostic and response-predictive tests for MDD provided a source of optimism for future clinical applications. However, such findings should be considered very carefully because their benefit/cost ratio and clinical indications were not clearly demonstrated. Future tests may include combinations of different types of biomarkers and be specific for MDD subtypes or pathological dimensions.
Collections Ireland -> Trinity College Dublin -> PubMed

Full list of authors on original publication

Alessandro Serretti, Dan Rujescu, Julien Mendlewicz, Sven Cichon, Florence Thibaut, David St Clair, YongYong Shi, Peter Propping, Jorge Ospina-Duque, Michael C O'Donovan and 21 others

Experts in our system

Dan Rujescu
Trinity College Dublin
Total Publications: 20
M C O'Donovan
Trinity College Dublin
Total Publications: 18