Journal Article


Colin Hill
Julian R Marchesi
Paul W. O'Toole


Agriculture & Food Science

probiotics generation products biotherapeutics food traditional class gut microbiota

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics. (2016)

Abstract The leading probiotics currently available to consumers are generally drawn from a narrow range of organisms. Knowledge of the gut microbiota and its constituent actors is changing this paradigm, particularly given the phylogenetic range and relatively unknown characteristics of the organisms under investigation as novel therapeutics. For this reason, and because their development is likely to be more amenable to a pharmaceutical than a food delivery route, these organisms are often operationally referred to as next-generation probiotics, a concept that overlaps with the emerging concept of live biotherapeutic products. The latter is a class of organisms developed exclusively for pharmaceutical application. In this Perspective, we discuss what lessons have been learned from working with traditional probiotics, explore the kinds of organisms that are likely to be used as novel microbial therapeutics, discuss the regulatory framework required, and propose how scientists may meet this challenge.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Colin Hill, Julian R Marchesi, Paul W. O'Toole

Experts in our system

Colin Hill
University College Cork
Total Publications: 351
Julian R Marchesi
University College Cork
Total Publications: 40
P W O'Toole
University College Cork
Total Publications: 72