Type

Journal Article

Authors

Jens Walter
Robert W Hutkins
Dan Knights
Pajau Vangay
Benjamin Hillmann
Douwe van Sinderen
Marco Ventura
Amy O'Callaghan
Francesca Bottacini
Inés Martínez
and 1 others

Subjects

Microbiology

Topics
humans stable gut microbiota gut pre treatment resident bifidobacterium longum human

Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome. (2016)

Abstract Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. Thus, phylogenetic limiting and resource availability are two factors that control the niche opportunity for AH1206 colonization. These findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precise and personalized microbiome reconstitution.
Collections Ireland -> University College Cork -> PubMed

Full list of authors on original publication

Jens Walter, Robert W Hutkins, Dan Knights, Pajau Vangay, Benjamin Hillmann, Douwe van Sinderen, Marco Ventura, Amy O'Callaghan, Francesca Bottacini, Inés Martínez and 1 others

Experts in our system

1
Douwe van Sinderen
University College Cork
 
2
Marco Ventura
University College Cork
Total Publications: 31
 
3
Amy O'Callaghan
University College Cork
Total Publications: 6
 
4
Francesca Bottacini
University College Cork