Type

Journal Article

Authors

Julie A Lovegrove
Helen M Roche
Ellen E Blaak
Wim H Saris
Ulf Risérus
José López-Miranda
Catherine DeFoort
Christian A Drevon
Aldona Dembińska-Kieć
Beata Kieć-Wilk
and 4 others

Subjects

Pharmacology

Topics
acid resistance fatty acids blood pressure fatty acid linear models low density lipoprotein cholesterol insulin resistance metabolic syndrome

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome. (2016)

Abstract Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Julie A Lovegrove, Helen M Roche, Ellen E Blaak, Wim H Saris, Ulf Risérus, José López-Miranda, Catherine DeFoort, Christian A Drevon, Aldona Dembińska-Kieć, Beata Kieć-Wilk and 4 others

Experts in our system

1
Julie A Lovegrove
University College Dublin
Total Publications: 46
 
2
Helen M. Roche
University College Dublin
Total Publications: 105
 
3
Ellen E Blaak
University College Dublin
Total Publications: 11
 
4
Wim H M Saris
University College Dublin
Total Publications: 39
 
5
Ulf Risérus
University College Dublin
 
6
José López-Miranda
University College Dublin
Total Publications: 18
 
7
Catherine Defoort
University College Dublin
Total Publications: 11
 
8
Christian A Drevon
University College Dublin
Total Publications: 39
 
9
Beata Kieć-Wilk
University College Dublin
Total Publications: 7