Type

Journal Article

Authors

John C Mathers
Wim Hm Saris
J Alfredo Martinez
Julie A Lovegrove
Lorraine Brennan
Eileen R Gibney
Marianne C Walsh
Mike J Gibney
Jildau Bouwman
Keith Grimaldi
and 18 others

Subjects

Psychiatry

Topics
weight loss therapy adult humans fto protein human health knowledge attitudes practice adolescent genotype female adipose tissue obesity genetic counseling genetics alleles disclosure young adult male risk factors genetic predisposition to disease middle aged etiology alpha ketoglutarate dependent dioxygenase fto europe body weight adiposity waist circumference polymorphism single nucleotide

Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial. (2016)

Abstract Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6.Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)].Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at clinicaltrials.gov as NCT01530139.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

John C Mathers, Wim Hm Saris, J Alfredo Martinez, Julie A Lovegrove, Lorraine Brennan, Eileen R Gibney, Marianne C Walsh, Mike J Gibney, Jildau Bouwman, Keith Grimaldi and 18 others

Experts in our system

1
John C Mathers
University College Dublin
Total Publications: 33
 
2
Wim H M Saris
University College Dublin
Total Publications: 39
 
3
J Alfredo Martinez
University College Dublin
Total Publications: 32
 
4
Julie A Lovegrove
University College Dublin
Total Publications: 46
 
5
Lorraine Brennan
University College Dublin
Total Publications: 166
 
6
Eileen R Gibney
University College Dublin
Total Publications: 98
 
7
Marianne C Walsh
University College Dublin
Total Publications: 51
 
8
Mike Gibney
University College Dublin
Total Publications: 24