Type

Journal Article

Authors

Michael Hutchinson
Seán O'Riordan
Richard B Reilly
Rebecca Beck
Shruti Narasiham
Brendan Quinlivan
John S Butler
Laura Williams
Ines Beiser
Emer O'Connor
and 1 others

Subjects

Physiotherapy & Sport

Topics
adult pre clinical future threshold temporal discrimination menstrual cycle sex ratio female

Menstrual cycle and the temporal discrimination threshold. (2017)

Abstract The temporal discrimination threshold (TDT) is a proposed pre-clinical biomarker (endophenotype) for adult onset isolated focal dystonia (AOIFD). Age- and sex-related effects on temporal discrimination demonstrate that women, before the age of 40 years, have faster temporal discrimination than men but their TDTs worsen with age at almost three times the rate of men. Thus after 40 years the TDT in women is progressively worse than in men. AOIFD is an increasingly female-predominant disorder after the age of 40; it is not clear whether this age-related sexually-dimorphic difference observed for both the TDT and sex ratio at disease onset in AOIFD is a hormonal or chromosomal effect. The aim of this study was to examine temporal discrimination at weekly intervals during two consecutive menstrual cycles in 14 healthy female volunteers to determine whether physiological hormonal changes affected temporal discrimination. We observed no significant differences in weekly temporal discrimination threshold values during the menstrual cycles and no significant correlation with the menstrual cycle stage. This observed stability of temporal discrimination during cyclical hormonal change raises interesting questions concerning the age-related sexually-dimorphic decline observed in temporal discrimination. Our findings pave the way for future studies exploring potential pathomechanisms for this age-related deterioration.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Michael Hutchinson, Seán O'Riordan, Richard B Reilly, Rebecca Beck, Shruti Narasiham, Brendan Quinlivan, John S Butler, Laura Williams, Ines Beiser, Emer O'Connor and 1 others

Experts in our system

1
Michael Hutchinson
University College Dublin
Total Publications: 79
 
2
Sean O'Riordan
Trinity College Dublin
Total Publications: 20
 
3
Richard Reilly
Trinity College Dublin
Total Publications: 183
 
4
Rebecca Beck
University College Dublin
Total Publications: 9
 
5
Brendan Quinlivan
Trinity College Dublin
Total Publications: 10
 
6
John S Butler
Trinity College Dublin
Total Publications: 27
 
7
Laura Williams
Trinity College Dublin
Total Publications: 13
 
8
Ines Beiser
Trinity College Dublin
Total Publications: 11