Type

Journal Article

Authors

Patrick Lonergan
Dimitrios Rizos
Alfonso Gutierrez-Adan
Thomas E Spencer
Alan D Ealy
Roger G Sturmey
Constantine A Simintiras
Peadar O'Gaora
Veronica Maillo
Niamh Forde

Subjects

Veterinary

Topics
mice female bovine cattle adult x chromosome genes x linked gene expression

Sexually Dimorphic Gene Expression in Bovine Conceptuses at the Initiation of Implantation. (2016)

Abstract In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inactivation (XCI) is required to ensure an equal transcriptional level of most X-linked genes for both male and female embryos in adult tissues, but this process is markedly different in cattle than mice. We examined how sexual dimorphism affected conceptus transcript abundance and amino acid composition as well as the endometrial transcriptome during the peri-implantation period of pregnancy. Of the 5132 genes that were differentially expressed on Day 19 in male compared to female conceptuses, 2.7% were located on the X chromosome. Concentrations of specific amino acids were higher in the uterine luminal fluid of male compared to female conceptuses, while female conceptuses had higher transcript abundance of specific amino acid transporters (SLC6A19 and SLC1A35). Of note, the endometrial transcriptome was not different in cattle gestating a male or a female conceptus. These data support the hypothesis that, far from being a blastocyst-specific phenomenon, XCI is incomplete before and during implantation in cattle. Despite differences in transcript abundance and amino acid utilization in male versus female conceptuses, the sex of the conceptus itself does not elicit a different transcriptomic response in the endometrium.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Patrick Lonergan, Dimitrios Rizos, Alfonso Gutierrez-Adan, Thomas E Spencer, Alan D Ealy, Roger G Sturmey, Constantine A Simintiras, Peadar O'Gaora, Veronica Maillo, Niamh Forde

Experts in our system

1
P. Lonergan
University College Dublin
Total Publications: 190
 
2
D Rizos
University College Dublin
Total Publications: 42
 
3
Alfonso Gutierrez-Adan
University College Dublin
Total Publications: 9
 
4
Thomas E Spencer
University College Dublin
Total Publications: 14
 
5
A D Ealy
University College Dublin
Total Publications: 3
 
6
Roger G Sturmey
University College Dublin
Total Publications: 4
 
7
Constantine A Simintiras
University College Dublin
Total Publications: 4
 
8
Peadar O'Gaora
University College Dublin
Total Publications: 11
 
9
V Maillo
University College Dublin
Total Publications: 8
 
10
N Forde
University College Dublin
Total Publications: 53