Journal Article


Christine Morand
Francisco Tomás-Barberán
Marina Heinonen
Eileen R Gibney
Rikard Landberg
Maria Teresa Garcia-Conesa
Baukje de Roos
Ana Rodriguez-Mateos
Tom Van de Wiele
Dragan Milenkovic
and 1 others


Agriculture & Food Science

bioactive compounds risk reduction aging food consumption age related diseases food risk individual differences healthy food

Addressing the inter-individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction. (2016)

Abstract Bioactive compounds in plant-based foods have health properties that contribute to the prevention of age-related chronic diseases, particularly cardiometabolic disorders. Conclusive proof and understanding of these benefits in humans is essential in order to provide effective dietary recommendations but, so far, the evidence obtained from human intervention trials is limited and contradictory. This is partly due to differences between individuals in the absorption, distribution, metabolism and excretion of bioactive compounds, as well as to heterogeneity in their biological response regarding cardiometabolic health outcomes. Identifying the main factors underlying inter-individual differences, as well as developing new and innovative methodologies to account for such variability constitute an overarching goal to ultimately optimize the beneficial health effects of plant food bioactives for each and every one of us. In this respect, this position paper from the COST Action FA1403-POSITIVe examines the main factors likely to affect the individual responses to consumption of plant food bioactives and presents perspectives for assessment and consideration of inter-individual variability.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Christine Morand, Francisco Tomás-Barberán, Marina Heinonen, Eileen R Gibney, Rikard Landberg, Maria Teresa Garcia-Conesa, Baukje de Roos, Ana Rodriguez-Mateos, Tom Van de Wiele, Dragan Milenkovic and 1 others

Experts in our system

Eileen R Gibney
University College Dublin
Total Publications: 98