Type

Journal Article

Authors

Ivan J. Perry
Christina B Dillon
Catherine M Phillips

Subjects

Physiotherapy & Sport

Topics
acute phase proteins blood male inflammation ireland physiology middle aged exercise moderate to vigorous physical activity motor activity insulin resistance complement component c3 cytokines adult physical activity humans cross sectional studies sedentary lifestyle prevention control pro inflammatory cytokines female adipocytokines obesity accelerometry adipokines

Does replacing sedentary behaviour with light or moderate to vigorous physical activity modulate inflammatory status in adults? (2017)

Abstract Background: Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. Limited data on whether physical activity modulates inflammatory status and counteracts obesity and insulin resistance associated low-grade inflammation exist. Our objective was to investigate associations between objectively measured physical activity and inflammatory status, and specifically whether substituting daily sedentary behaviour with light activity or moderate to vigorous physical activity (MVPA), is associated with beneficial alterations to the inflammatory profile among middle-aged adults and those at increased cardiometabolic risk (obese and insulin resistant subjects). Methods: Data are from a sub-sample of the Mitchelstown cohort; a population-based cross-sectional sample of 2047 Irish adults. Physical activity intensity and duration were measured in 396 participants for 7-consecutive days using the GENEActiv accelerometer. Isotemporal regression analysis examined the associations between replacing 30 min per day of sedentary behaviour with equal amounts of light activity and MVPA on inflammatory factors (serum acute-phase reactants, adipocytokines, pro-inflammatory cytokines and white blood cells (WBC)). Results: Reallocating 30 min of sedentary time with MVPA was associated with a more favourable inflammatory profile characterized by higher adiponectin and lower complement component C3 (C3), leptin, interleukin 6 (IL-6) and WBC concentrations (P < 0.05). No significant effects were noted with substitution of sedentary time with light activity. Among the obese subjects replacing sedentary behaviour with an equivalent amount of MVPA was associated with lower WBC counts (P < 0.05); no associations were detected among the insulin resistant (HOMA-IR >75th percentile) subjects. Among the non-obese and non-insulin resistant subjects substituting 30 min of sedentary behaviour with MVPA was associated with decreased C3, IL-6 and WBC concentrations. Conclusions: Replacing sedentary behaviour with MVPA modulates pro-inflammatory status. These findings, which highlight the need for the developing randomized trials aimed at lowering cardiometabolic risk, warrant further investigation
Collections Ireland -> University College Cork -> Public Health
Ireland -> University College Cork -> HRB Centre for Health and Diet Research - Journal Articles
Ireland -> University College Cork -> College of Medicine and Health
Ireland -> University College Cork -> HRB Centre for Health and Diet Research
Ireland -> University College Cork -> Public Health - Journal Articles
Ireland -> University College Cork -> Research Institutes and Centres

Full list of authors on original publication

Ivan J. Perry, Christina B Dillon, Catherine M Phillips

Experts in our system

1
Ivan J Perry
University College Cork
Total Publications: 188
 
2
Christina B Dillon
University College Cork
Total Publications: 14
 
3
Catherine M Phillips
University College Cork
Total Publications: 44