Type

Journal Article

Authors

Song Miao
Alan L Kelly
Wei Lu

Subjects

Agriculture & Food Science

Topics
influence surface charge gastrointestinal tract git simulated digestion droplet size digestion emulsions cellular uptake bioavailability size structure emulsion carotene

Bioaccessibility and cellular uptake of β-carotene encapsulated in model O/W emulsions: influence of initial droplet size and emulsifiers (2017)

Abstract The effects of the initial emulsion structure (droplet size and emulsifier) on the properties of β-carotene-loaded emulsions and the bioavailability of β-carotene after passing through simulated gastrointestinal tract (GIT) digestion were investigated. Exposure to GIT significantly changed the droplet size, surface charge and composition of all emulsions, and these changes were dependent on their initial droplet size and the emulsifiers used. Whey protein isolate (WPI)-stabilized emulsion showed the highest β-carotene bioaccessibility, while sodium caseinate (SCN)-stabilized emulsion showed the highest cellular uptake of β-carotene. The bioavailability of emulsion-encapsulated β-carotene based on the results of bioaccessibility and cellular uptake showed the same order with the results of cellular uptake being SCN > TW80 > WPI. An inconsistency between the results of bioaccessibility and bioavailability was observed, indicating that the cellular uptake assay is necessary for a reliable evaluation of the bioavailability of emulsion-encapsulated compounds. The findings in this study contribute to a better understanding of the correlation between emulsion structure and the digestive fate of emulsion-encapsulated nutrients, which make it possible to achieve controlled or potential targeted delivery of nutrients by designing the structure of emulsion-based carriers
Collections Ireland -> University College Cork -> College of Science, Engineering and Food Science
Ireland -> University College Cork -> Food and Nutritional Sciences - Journal Articles
Ireland -> University College Cork -> Food and Nutritional Sciences

Full list of authors on original publication

Song Miao, Alan L Kelly, Wei Lu

Experts in our system

1
Song Miao
Teagasc
Total Publications: 28
 
2
Alan L. Kelly
Teagasc
Total Publications: 63
 
3
Wei Lu
Teagasc
Total Publications: 7